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There was a measurable worsening but not
2019-07-02

There was a measurable worsening, but not a statistically significant change in the baseline and follow-up best ear hearing scores, where the mean worsening change was 11.9 dB (95% CI: −1.11–24.86, p-value = 0.070). However, of the 16 patients, 14 (87.5%) were found to have clinically significant wo
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br Transparency document br Results
2019-07-02

Transparency document Results and Discussion Experimental Procedures Acknowledgments The casein kinase 1 (CK1) family consists of at least seven different gene products, often referred to as isoforms (α, β, γ1, γ2, γ3, δ, ε, with splice forms described for CK1α, γ, and ε (reviewed in )
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Resistance to avermectins has been associated
2019-07-02

Resistance to avermectins has been associated with point mutations of GluCls in C. elegans, D. melanogaster, T. urticae and P. xylostella (Dent et al., 2000; Dermauw et al., 2012; Kane et al., 2000; Kwon et al., 2010; Wang et al., 2016a, 2017). Our electrophysiological study found a 8.2-fold reducti
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During the entire life of individual articular chondrocyte a
2019-07-02

During the entire life of individual, articular chondrocyte as well as subchondral bone receives acute or chronic stress. Joints homeostasis is maintained by biomechanical stress, as rapid loss of proteoglycan in joints occurs due to immobilization or disuse. These osteophytes are fibrocartilage cap
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br Acknowledgements br Introduction Chemokines
2019-07-02

Acknowledgements Introduction Chemokines are a superfamily of chemotactic cytokines that play important roles in regulating cell migration and activation under inflammatory conditions (Nomiyama et al., 2008; Peatman and Liu, 2007; Zlotnik and Yoshie, 2000), such as angiogenesis (Arenberg et al
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Most data regarding fish CXCR functions have accumulated
2019-07-02

Most data regarding fish CXCR4 functions have accumulated from work in zebrafish where a range of genetic tools and imaging technologies have been developed. As mentioned above, in teleost fish the two CXCR4s (CXCR4a and 4b) are assumed to interact with two ligands (CXCL12a and 12b) and this differe
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Various domains of the HSA molecule
2019-07-02

Various domains of the HSA molecule have also been used to make bioconjugates with increased stability, better targeting properties, and/or extended half-lives in blood. For example, domain I of HSA has been used in the preparation of antibody conjugates. This was achieved through the use of a cyclo
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Although we observed increases in AR mediated cAMP productio
2019-07-02

Although we observed increases in α1-AR mediated cAMP production separately in the nucleus and cytoplasm, compartment specificity was observed for PKA activation. GPCRs and their effector proteins are commonly found in multiprotein signalosomes with A-kinase anchoring proteins (AKAPs) serving as sca
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Berberine The H E staining and Nissl
2019-07-02

The H&E staining and Nissl staining results showed that damage to the pyramidal neurons in the CA1 and CA3 regions of the hippocampus were observed in the 50 mg/kg/day DBP group, accompanied by an absence of Nissl bodies, suggesting that DBP exposure can lead to pathological changes in the neurons o
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Diagnosis of pituitary metastasis could be
2019-07-01

Diagnosis of pituitary metastasis could be missed by medical practitioners because most patients who developed pituitary metastasis are clinically asymptomatic. Patients may have signs and symptoms of nausea, vomiting, fatigue, and weight loss, which could also be viewed as pan-hypopituitarism, and
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caspofungin of MCL has a poor long term response to current
2019-07-01

MCL has a poor long-term response to current treatment strategies, for the most commonly used R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone), the remission rate is good (75–96%) but brief in duration. Despite the study of several other chemotherapy regimens
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Las formas transmisibles no del
2019-07-01

“Las formas transmisibles, no del saber o de la sabiduría de un hombre, sino sobre todo su vida vivida —y esa es la materia con que se hacen historias— sólo son adquiridas al morir”, afirma Walter Benjamin. La muerte atraviesa toda la Historia verdadera: como motivo, como temor, como asombro o recue
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Assim pensamos que os discursos analisados neste
2019-07-01

Assim, pensamos que os discursos, analisados neste artigo, construídos pelos intelectuais colaboradores de Araucaria de Chile e difundidos pela revista, ao ressaltarem duas vitoriosas revoluções armadas latino-americanas, exatamente no período de vigência da prpm, dialogaram, de alguma maneira, com
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In conclusion a rare KCNE
2019-06-29

In conclusion, a rare KCNE1-D85N polymorphism may modify the LQTS phenotype in combination with other pathogenic LQTS-related gene mutations. Disclosures Conflict of interest Acknowledgments Introduction Atrial fibrillation (AF) is observed in 10–30% of patients with symptomatic Strepto
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The presence of AHRE however may not invariably indicate the
2019-06-29

The presence of AHRE, however, may not invariably indicate the presence of ATA. We have recently reported AHRE that reflected episodes of atrial fibrillation (AF) as well as device-mediated arrhythmic events, such as repetitive non-reentrant ventriculo-atrial synchrony (RNRVAS), Cyclic Pifithrin-α h
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