• Polyunsaturated fatty acid components of

  2021-09-23

  

  Polyunsaturated fatty things components of brain are more prone to oxidative attack, an event called lipid peroxidation. Consistent with previous findings on neurotoxicity [58,59], colistin sulphate increased the level of MDA in the brain of rats. The elevated MDA, a consequence of overwhelmed antio

• PDEs block GUCY C associated second

  2021-09-23

  

  PDEs block GUCY2C-associated second messenger signaling by degrading cyclic nucleotides, whereas inhibition of PDEs activity prevents cyclic nucleotide degradation (Fig. 1). Several researchers have described the pathophysiological roles of various PDEs in numerous tumor cell types, including CRC Ni

• br Acknowledgements This work was supported by a grant from

  2021-09-23

  

  Acknowledgements This work was supported by a grant from the BBSRC (BB/D011809/1) to GJL and The Royal Society to SHS (Uf090321). SIM and AH were the recipients of scholarships from HEC Pakistan. Introduction Iron (Fe) is the fourth most abundant element in the earth’s crust. However, Fe is o

• br Acknowledgments br Introduction Myelin one of the fundame

  2021-09-23

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the orexin receptor antagonist of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwan

• Next to their indirect effect on ASBT expression

  2021-09-23

  

  Next to their indirect effect on ASBT expression, microbiota are also directly involved in BA homeostasis and FXR-FGF15/19 signaling. Different species of intestinal microbiota have the ability to biotransform BAs mainly by deconjugation and subsequent de-hydroxylation, the latter resulting in more

• Chrysin One important discovery of our study is the identifi

  2021-09-23

  

  One important discovery of our study is the identification of a pharmacological mechanism for the macrolide antibiotic erythromycin (EM) in promoting joint health. EM is a commonly used antibiotic that directly binds bacterial ribosomes to inhibit protein synthesis [66]. Although EM-like macrolide C

• In order to test the influence

  2021-09-23

  

  In order to test the influence of the initial depolarization, experiments were performed, where the degree of chloride substitution was varied, either by adding n-Ringer to Terfenadine incubated in a sucrose Ringer or by suspending the cells directly in Ringers identical to the final composition in

• According to Laplace s law loss

  2021-09-22

  

  According to Laplace’s law, loss of myogenic response would increase wall stress and tension in downstream vessels and subsequently induce endothelial dysfunction and arterial stiffness [36]. Indeed, we found that arteries from FPR-1 KO mice presented with a leftward shift in the stress-strain curve

• Recently they reported an enyne

  2021-09-22

  

  Recently, they reported an enyne chemotype agonist (21, Fig. 13) with low lipophilicity, small polar surface area (PSA) and high potency (Clog P=3.8, tPSA=37 A2, EC50=20nM), further derived from TUG-424. The compound endowed fast oral Mevastatin synthesis (tmax=15min) and a decent pharmacokinetic p

• Previous studies have shown that

  2021-09-22

  

  Previous studies have shown that Cu(I) neurotoxicity includes induction of ROS with involvement of the NF-kB pathway and apoptosis (Butterworth, 2010) and that, in its Cu(I) state, Cu(I) alters microglia phenotype and inhibits nitric oxide release (Rossi-George et al., 2012). Cu(I) has a great affin

• The observed glucose intolerance and elevated fasting blood

  2021-09-22

  

  The observed glucose intolerance and elevated fasting blood glucose in this study is in consonance with earlier study (Ferris and Kahn, 2012). These have been the common features of GC exposure and are not unexpected. Previous researches that reported IR during GC exposure have shown controversy con

• Finally we investigated increasing basicity

  2021-09-22

  

  Finally, we investigated increasing basicity as a way to improve solubility. We expected that conversion of the ether linkage of to an -methyl group could improve solubility. More than expected, cysteine protease demonstrated significant improvement of values of solubility for the two media, espe

• br Materials and methods br Results

  2021-09-22

  

  Materials and methods Results Analysis of the post-mortem human prefrontal cortex by western blotting indicated that GLAST expression was increased 1.6-fold in the extracts of alcoholic brains relative to controls (Fig. 1A and B). To resolve the distinct sub-pools of GLAST within our samples w

• Work in the Ruiz i Altaba

  2021-09-22

  

  Work in the Ruiz i Altaba lab was funded by grants from the Swiss National Science Foundation, the Ligue Suisse Contre le Cancer, the European FP7 Marie-Curie Initial Training Network HEALING, a James McDonnell Foundation 21st Century Science Initiative in Brain Cancer-Research Award and funds from

• Numerical models of blood regulation provide insight

  2021-09-18

  

  Numerical models of blood regulation provide insight into the interaction of the cellular-level and macro-scale phenomena studied in silico, a term referring to computer simulations of the dynamics of complex biological systems as opposed to in vivo or in vitro experimental studies. These in silico

15650 records 559/1044 page Previous Next First page 上5页 556557558559560 下5页 Last page