• br Conclusion br Introduction Free

  2018-11-02

  

  Conclusion Introduction Free fibular osteocutaneous flaps are used worldwide for mandibular defect reconstruction after tumor ablation of head and neck cancer. Although these flaps have generally been accepted as suitable sources of vascularized bone grafts, donor-site morbidity remains a conc

• br Conclusion br Introduction Hemangioblastomas are predomin

  2018-11-02

  

  Conclusion Introduction Hemangioblastomas are predominantly present in the cerebellum, RepSox stem, and spinal cord. They rarely occur in supratentorial locations. These tumors may occur sporadically or be associated with von Hippel–Lindau disease (VHL). Here we report a case of a 52-year-old

• Givinostat Introduction Obesity is a metabolic disorder and

  2018-11-02

  

  Introduction Obesity is a metabolic disorder and can be defined as increased body weight caused by excessive fat accumulation which presents a risk to health with an increase in health problems and/or reduced life expectancy [1,2]. Obesity is characterized by an increased storage of triglycerides i

• Limitations for neural stem progenitor cells include in vitr

  2018-11-02

  

  Limitations for neural stem/progenitor cells include in vitro expansion for transplantation as well as loss of capacity to differentiate when expanded in vitro which limit their ability to form functional grafts (Svendsen et al., 1996) with lack of generation of specific cell types such as dopaminer

• br Experimental Procedures br Acknowledgments We

  2018-11-02

  

  Experimental Procedures Acknowledgments We are grateful to S. Yamanaka (University of Kyoto) for providing the plasmid and retroviral vectors through Addgene, and to T. Kitamura (University of Tokyo) for providing PlatE cells. We thank A. Nifuji, H. Ideno, and T. Kamada for helpful discussions

• Reprogrammation of CD cells from LRFs towards induced plurip

  2018-11-02

  

  Reprogrammation of CD34+ dihydroergotamine from LRFs towards induced pluripotent stem cells (iPS cells) could also be proposed and tested. Chou et al. (2011) and others cited by them succeeded in obtaining iPS cells from adult blood CD34+ cells without viral integration and showed that blood cells h

• br Results br Discussion Our first goal in

  2018-11-02

  

  Results Discussion Our first goal in these studies was to establish an immunodeficient mouse model of hyperglycemia associated with insulin resistance and obesity that would resemble a type 2 diabetes phenotype. It was not feasible to transplant human progenitor cells into traditional models o

• However to increase emission efficiency these hot electrons

  2018-11-02

  

  However, to increase emission efficiency, these hot electrons have to reach the outer emitter boundary and to remain in its vicinity for a relatively long time without relaxation. According to recent studies [65,66], such possibility appears if the considered medium is composed by nanoparticles with

• their mathematical expectations follow the expressions br Ac

  2018-11-02

  

  their mathematical expectations follow the expressions According to the CLT for independent random variables , for N → ∞  the expression tends to a standardized Gaussian random variable. Therefore for N ≫ 1 we have the following approximate equalities: where θ0, , are the standardized Gaussian

• The phase composition of the potassium

  2018-11-02

  

  The phase composition of the potassium-ammonium nitrate mixture was studied in [15,16]. Solid solutions of ammonium nitrate dissolved in potassium nitrate form only for temperatures lower than 298 K. For higher temperatures, there is a larger amount of another phase that is a solid solution of ammon

• Sleep disturbances and non restorative sleep are

  2018-11-01

  

  Sleep disturbances and non-restorative sleep are frequently occurring in patients with anxiety and depressive disorders (AND) [1,2,5–7]. Compared to healthy subjects, both insomnia (40–90%) and hypersomnia (5–10%) are more common in depression and related affective disorders. Persistent sleep distur

• Cisplatin Additionally we showed that treatment with the sam

  2018-11-01

  

  Additionally, we showed that treatment with the same AntagoNAT induced SCN1A upregulation in human cells with different mutation types (Fig. 11), thus opening the possibility of using one AntagoNAT for the treatment of many Dravet patients, as opposed to designing a separate molecule for each mutati

• We found that smoking cessation is beneficial in reducing

  2018-11-01

  

  We found that smoking cessation is beneficial in reducing and delaying lung cancer and this beneficial effect does not vary with CHRNA5 rs16969968, which is a genetic marker for nicotine dependence (Liu et al., 2010; Saccone et al., 2010; TAG, 2010; Thorgeirsson et al., 2010), lung cancer (Amos et a

• Fluid phase endocytosis involves several

  2018-11-01

  

  Fluid-phase endocytosis involves several endocytic mechanisms that are characterized by fluids as a cargo (reviewed in (Doherty and McMahon, 2009)). While we did not characterize further the mechanism regulating FPE involved during ADM, we show here that the central regulatory role of RAC1 in ADM fo

• The rationale for use of

  2018-11-01

  

  The rationale for use of FASN inhibitors as a key component of combination therapy derives from known cellular effects of FASN inhibition (Ventura et al., 2015; Chuang et al., 2011; Kridel, 2004; Puig et al., 2009, 2008; Tomek et al., 2011) that include (1) blockade of palmitate synthesis, (2) disru

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